Possible identification of CENP-C in fish and the presence of the CENP-C motif in M18BP1 of vertebrates. [version 2; referees: 2 approved]

Possible identification of CENP-C in fish and the presence of the CENP-C motif in M18BP1 of vertebrates. [version 2; referees: 2 approved]

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The centromeric protein CENP-C is a simply southern cat shirt base component of the kinetochore.This protein, along with CENP-A has been shown to adaptively evolve in a number of animal and plant species.In order to determine if CENP-C also evolves in fish species, I attempted to retrieve fish CENP-C sequences from GenBank.

No Teleostei CENP-C sequences were found either by name or by BLASTP searches with the vertebrate CENP-C motif sequence.A number of putative Teleostei protein sequences were identified in GenBank that have homology 1073spx to the C-terminal cupin domain of vertebrate CENP-C.These proteins only have partial homology to the CENP-C motif, but evidence is presented that makes it likely that these fish proteins are orthologs of CENP-C.

Interestingly, it was also discovered that the CENP-C motif sequence is also mostly present in M18BP1 proteins of fish and some other vertebrates but not in mammals.This finding may have implications for CENP-C and M18BP1 assembly in centromeric regions of different vertebrate taxa.